Hypervalent Iodine‐Mediated Late‐Stage Peptide and Protein Functionalization

Hypervalent iodine compounds are powerful reagents for the development of novel transformations. As they exhibit low toxicity, high functional group tolerance, and stability in biocompatible media, have been used functionalization biomolecules. Herein, we report recent advances up to June 2021 peptide protein modification using hypervalent reagents. Their use as transfer or oxidizing is discussed this Minireview, including methods targeting polar, aromatic, aliphatic amino acids termini.